Ernst Bomhard

Ernst Bomhard

Education:

1971 Graduation in veterinary medicine at the university of Munich, Germany
1974 Completion of doctoral thesis in the faculty of veterinary medicine, university of Munich, Germany.

Professional experience:

1974-1986 Head of laboratory at the institute of toxicology in the pharmaceutical division of Bayer AG in Wuppertal, Germany
1986-1995 Deputy head of industrial toxicology at the institute of toxicology of the pharmaceutical division of Bayer AG in Wuppertal, Germany
1995-1999 Head of carcinogenicity and genotoxicity at the institute of toxicology of the pharmaceutical division of Bayer AG in Wuppertal, Germany
1999-2002 Head of industrial toxicology at the institute of toxicology of the pharmaceutical division of Bayer AG in Wuppertal, Germany
since 2003 Independent consultant to the pharmaceutical and chemical industry in toxicology and specifically in carcinogenicity and genotoxicity

Representation:

1982-2003 Representative of Bayer AG in 6 ECETOC Task Forces
1983-1984 Representative of Bayer AG in the VCI working group "Neurotoxicology" (chairman)
1983-1984 Representative of the VCI in the BGA working group for the development of a test guideline "Behavioral Testing in Animal Experiments"
1988-1993 Member of the CEFIC Sector group EBMA (European BHT Manufacturers Association) representing Bayer AG; chairman of the toxicology working group
1998-2002 Representative of Bayer AG in the VCI working group "Toxicology"
1998-2002 Member of the CEFIC sector group CES (Centre Europeen des Silicones) representing GE Bayer Silicones; chairman of the health working group
2000-2003 Member of the ECETOC Scientific Committee representing Bayer AG

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Publications in journals/ books (selection, status 2003):

  1. BOMHARD E, SCHULZ V, GROPP J (1975)
    Zur Bestimmung von Vitamin K-Aktivität im biologischen Verfahren. 1. Mitteilung: Vitamin K, Wirkungsweise und biologische Bestimmung.
    Z Tierphysiol, Tierernähr Futtermittelk 34:237-252
  2. BOMHARD E, LÖSER E, DORNEMANN A, SCHILDE B (1982)
    Subchronic oral toxicity and analytical studies on Nickel Rutile Yellow and Chrome Rutile Yellow with rats.
    Toxicol Lett 14:189-194
  3. BOMHARD E, MARUHN D, PAAR D, WEHLING K (1984)
    Urinary enzyme measurements as sensitive indicators of chronic Cadmium nephrotoxicity. In: Contributions to Nephrology; Kidney, Small proteins and Drugs.
    Karger, Basel, Vol. 42, pp. 142-147
  4. BOMHARD E, MARUHN D, VOGEL O (1985/1986)
    Comparative investigations on the effects of acute intraperitoneal Cadmium, Chromium, and Mercury exposure on the kidney.
    Uremia Investigations 9:131-136
  5. BOMHARD E, KARBE E, LÖSER E (1986)
    Spontaneous tumours of 2000 Wistar TNO/W70 rats in 2-year carcinogenicity studies.
    J Environ Pathol Toxicol Oncol 7:35-52
  6. BOMHARD E, VOGEL O, LÖSER E (1987)
    Chronic effects of single and multiple oral and subcutaneous Cadmium administration on the testes of Wistar rats.
    Cancer Lett 36: 307-315
  7. BOMHARD E, MARUHN D (1988)
    Effects of Puromycin aminonucleoside on ten urinary enzymes in rats.
    Arch Toxicol Suppl 12:158-161
  8. BOMHARD E, LUCKHAUS G, VOIGT WH, LÖSER E (1988)
    Induction of light hydrocarbon nephropathy by p-dichlorobenzene.
    Arch Toxicol 61:433-439
  9. BOMHARD E, MOHR U (1989)
    Spontaneous tumours in NMRI mice from carcinogenicity studies.
    Exp Pathol 36:129-145
  10. BOMHARD E, LUCKHAUS G, MARSMANN M, ZYWIETZ A (1989)
    Induction of hyaline droplet accumulation in renal cortex of male rats by aromatic compounds. In: Nephrotoxicity: Extrapolation from in vitro to in vivo and from animals to man.
    Eds.: Bach PH, Lock EA, Plenum Press, London, pp. 551-556
  11. BOMHARD E, SCHMIDT U, KARBE E (1989)
    Differences in liver sensitivity to methyl carbamate between Wistar and Fischer 344 rats.
    Arch Toxicol Suppl 13:319-321
  12. BOMHARD E, MARUHN D, VOGEL O, MAGER H (1990)
    Determination of urinary glutathione S-transferase and lactate dehydrogenase for differentiation between proximal and distal nephron damage.
    Arch Toxicol 64:269-278
  13. BOMHARD E, MARSMANN M, RÜHL-FEHLERT CH, ZYWIETZ A (1990)
    Relationships between structure and induction of hyaline droplet accumulation in the renal cortex of male rats by aliphatic and alicyclic hydrocarbons.
    Arch Toxicol 64:530-538
  14. BOMHARD E, MARUHN D, MAGER H (1991)
    Urinary glutathione S-transferase in several models of primary glomerular, distal tubular or papillary damage. In: Nephrotoxicity: Mechanisms, early diagnosis and therapeutic management.
    Eds.: Bach PH, Gregg NJ, Wilks MF, Delacruz L, Marcel Dekker Inc., New York-Basel-Hongkong, pp. 571-574
  15. BOMHARD E, MARSMANN M, ZYWIETZ A (1991)
    Structure toxicity model of light hydrocarbon nephropathy. In: Nephrotoxicity: Mechanisms, early diagnosis and therapeutic management.
    Eds.: Bach PH, Gregg NJ, Wilks MF, Delacruz L, Marcel Dekker Inc., New York-Basel-Hongkong, pp. 279-283
  16. BOMHARD E, MARSMANN M, RÜHL-FEHLERT CH, SCHADE-LEHN R, SCHÜÜRMANN G (1991)
    Screening of aromatic compounds for their potency of inducing hyaline droplet accumulation in male rat kidney. In: Nephrotoxicity: Mechanisms, early diagnosis and therapeutic management.
    Eds.: Bach PH, Gregg NJ, Wilks MF, Delacruz L, Marcel Dekker Inc., New York-Basel-Hongkong, pp. 273-277
  17. BOMHARD E, MARUHN D, MAGER H (1991)
    Excretion of urinary enzymes in female Sprague-Dawley rats in relation to cellular compartment, creatinine excretion and diuresis.
    Europ J Clin Chem Clin Biochem 29:775-782
  18. BOMHARD E (1992)
    Heavy metals. In: Urinary enzymes in clinical and experimental medicine.
    Eds.: Jung K, Mattenheimer H, Burchardt U, Springer Verlag, Berlin-Heidelberg-New York-London-Paris-Tokyo, pp. 281-290
  19. BOMHARD E (1992)
    Model substances. In: Urinary enzymes in clinical and experimental medicine.
    Eds.: Jung K, Mattenheimer H, Burchardt U, Springer Verlag, Berlin-Heidelberg-New York-London-Paris-Tokyo, pp. 290-296
  20. BOMHARD E, BREMMER JN, HERBOLD BA (1992)
    Review of the mutagenicity/genotoxicity of butylated hydroxytoluene.
    Mutat Res 277:187-200
  21. BOMHARD E (1992)
    Frequency of spontaneous tumors in Wistar rats in 30-month studies.
    Exp Toxic Pathol 44:381-392
  22. BOMHARD E (1993)
    Frequency of spontaneous tumors in NMRI mice in 21-month studies.
    Exp Toxic Pathol 45:269-289
  23. BOMHARD E, RINKE M (1994)
    Frequency of spontaneous tumors in Wistar rats in 2-year studies.
    Exp Toxic Pathol 46:17-29
  24. BOMHARD E, FALKENBERG FW, LOOF I (1994)
    Changes in urinary enzymes and kidney-derived antigens after acute renal papillary necrosis in rats.
    Kidney Int 46:60-63
  25. BOMHARD E (1996)
    Toxicology of glucosidase inhibitors. In: Handbook of Experimental Pharmacology; Volume 119 "Oral Antidiabetics".
    Eds.: Kuhlmann J, Puls W, Springer Verlag, Barcelona-Berlin-Budapest-Heidelberg-Hongkong-London-Milan-New York-Paris-Santa Clara-Singapore-Tokyo, pp. 557-610
  26. BOMHARD E, MÄRTINS T, RAMM W, RUF J, SUBERG H (1996)
    Acute Toxicologic Evaluation of Eight Chemicals Used in the Synthetics Division.
    J Am Coll Toxicol 15, Suppl 1, S55-S62
  27. BOMHARD E, KIMMERLE G, LÖSER E, MÄRTINS T, MIHAIL F, PAULUHN J, SUBERG H, THYSSEN J (1996)
    Acute Toxicologic Evaluation of Nineteen WTR Substances.
    J Am Coll Toxicol 15, Suppl 1, S63-S81
  28. BOMHARD E, LÖSER E, MÄRTINS T, PAULUHN J, RAMM W, RUF J (1996)
    Acute Toxicologic Evaluation of Twelve Chemicals Used in the Rubber Division.
    J Am Coll Toxicol 15, Suppl 1, S82-S93
  29. BOMHARD E, BOMANN W, HEIMANN K, KRÖTLINGER F, LESER KH, MÄRTINS T, PAULUHN J, RAMM W, SCHMIDT M, VOHR HW (1996)
    Acute Toxicologic Evaluation of Eight Chemicals Used in the Pharmaceutical Division.
    J Am Coll Toxicol 15, Suppl 1, S94-S103
  30. BOMHARD E, LÖSER E (1996)
    Acute Toxicologic Evaluation of Six Compounds Used in the Inorganic Chemical Business Group.
    J Am Coll Toxicol 15, Suppl 1, S104-S109
  31. BOMHARD EM (1997)
    Investigations on the sensitizing potential of p-chloro-m-cresol in Guinea pigs and their human relevance.
    Dermatosen 45:70-74
  32. BOMHARD EM, KRINKE GJ, ROSSBERG WM, SKRIPSKY Th (1997)
    Trimethylphosphate - A 30 month chronic toxicity/carcinogenicity study in Wistar rats with administration in drinking water.
    Fundam Appl Toxicol 40:75-89
  33. BOMHARD E, DIESING L, JÄGER R, KIMMERLE G, KOLB J, KRÖTLINGER F, LÖSER E, MÄRTINS T, PAULUHN J, RAMM W, RUF J, SUBERG H, THYSSEN J (1997)
    Acute toxicologic evaluation of 32 chemicals used in the rubber division.
    Int J Toxicol 16 (Suppl.2 ):1-9, 28-53
  34. BOMHARD E, HEIMANN K, LÖSER E, MÄRTINS T, PAULUHN J, RAMM W, ROSSBERG WM, SUBERG H, STROPP G, VOHR HW (1997)
    Acute toxicologic evaluation of 23 chemicals used in the pharmaceutical division.
    Int J Toxicol 16 (Suppl. 2):10-21, 54-67
  35. BOMHARD E, BISCHOFF H, MAGER H, KRÖTLINGER F, SCHILDE B (1998)
    D-Glucose - Combined chronic toxicity and carcinogenicity studies in Sprague-Dawley rats and Syrian golden hamsters.
    Drug Chem Toxicol 21:329-353
  36. BOMHARD EM, SCHMIDT U, LÖSER E (1998)
    Time-course of enzyme induction in liver and kidneys and absorption, distribution and elimination of 1,4-dichlorobenzene in rats.
    Toxicology 131: 73-91
  37. BOMHARD EM, MARUHN D, RINKE M (1999)
    Time course of chronic oral cadmium nephrotoxicity in Wistar rats: excretion of urinary enzymes.
    Drug and Chemical Toxicology 22: 679-703
  38. BOMHARD E, DIESING L, KIMMERLE G, KRÖTLINGER F, LÖSER E, MÄRTENS T, MIHAIL F, PAULUHN J, RAMM W, RUF J, SCHLADT L, SUBERG H, THYSSEN J (2000)
    Acute and subacute toxicologic evaluation of 43 chemicals.
    Int J Toxicol 19: 331-357; 368-369
  39. BOMHARD EM, BRENDLER-SCHWAAB SY, FREYBERGER A, HERBOLD BA, LESER KH, RICHTER M (2002)
    O-phenylphenol and its sodium and potassium salts: a toxicological assessment.
    Crit Rev Toxicol 32: 551-626
  40. BOMHARD EM (2003)
    High-dose clastogenic activity of aniline in the rat bone marrow and its relationship to the carcinogenicity in the spleen of rats.
    Arch Toxicol 77: 191-197
  41. BOMHARD EM, HERBOLD BA (2005)
    Genotoxic activities of aniline and its metabolites and their relationship to the carcinogenicity of aniline in the spleen of rats.
    Crit Rev Toxicol 35: 783-835

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