Hans-Werner Vohr

Hans-Werner Vohr

Education:

1979 Diploma in biology at the university of Würzburg, Germany (immunobiology, toxicology, genetics)
1983 Promotion at the institute of genetics at the university of Cologne, Germany (immunology)
1996 Venia Legendi for immunology at the university of Düsseldorf, Germany
2003 Appointment as adjunct professor of the university of Düsseldorf, Germany

Professional Experience:

1983-1986 Postdoc time at the university of Würzburg, institute of virology and immunobiology
1986-1989 Assistent at the medical institute of environmental hygiene, department of immunotoxicology, Düsseldorf
1989-2015 Bayer AG, toxicology, immunotoxicology (Head and Principal Expert for Immunotoxicology)

Besides:

  • Supply teacher at the gymnasium of Erftstadt, Germany (biology)

  • Lecturer at the university of Düsseldorf (immunology), advanced training course of DGPT (immunotoxicology) and master degree program toxicology at the Charité, the university of Vienna, Düsseldorf and Kaiserslautern

  • Radiation protection officer, project leader genetic engineering

  • Expert in (photo)allergy/(photo)irritation/immunotoxicology

  • Representative in TF of OECD, ECETOC, ILSI/HESI (ITC), DIA und ITCASS

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Publications:

Books:

  1. Publishing of "Encyclopedic References in Immunotoxicology"
    Springer-Verlag (2004 und 2015)
  2. Publishing of "Toxikologie" Band 1 und 2
    Wiley-Verlag (2010)

In journals:

  1. Vohr, H.-W., Karmann, G., Holtkamp, B., Neuerburg, J., Ploegh, H., Cramer, M. and Rajewsky, K.
    Functional and biochemical studies on somatic variants.
    In: Mechanisms of Lymphocyte Activation, Elsevier, Amsterdam: 468 (1981)
  2. Vohr, H.-W. and Schimpl, A.
    Analysis of the antibody responses to T dependent antigens in fully allogeneic chimeras.
    Behring Inst. Mitt. 70: 173 (1982)
  3. Vohr, H.-W., Holtkamp, B. and Rajewsky, K.
    Somatic H-2k variants reveal nonidentity of serological and cytotoxic T cell-defined Kk determinants.
    Eur. J. Immunol. 13: 846 (1983)
  4. Vohr, H.-W. and Hünig, T.
    Induction of proliferative and cytotoxic responses in resting Lyt2+ T cells with lectin and recombinant interleukine 2.
    Eur. J. Immunol. 15: 332 (1985)
  5. Vohr, H.-W. and Hünig, T.
    Polyclonal activation of cytotoxic T-lymphocytes (CTL) from resting Lyt2+ precursor cells requires only IL-2 as an exogenous lymphokine.
    In: Cellular and Molecular Biology of Lymphokines, Academic Press, Orlando, Florida: 87 (1985)
  6. Heckl, W., Jocham, K., Tauber, J. and Vohr, H.-W.
    Identification of inhibitory growth factors from a N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced murine bladder cancer cell line.
    Urol. Int. 42(4): 271-276 (1987)
  7. Gleichmann, E., Vogeler, S., Mirtschewa, J. and Vohr, H.-W.
    Possible pathogeneic pathways of chemically induced autoimmunity: studies in experimental animals.
    Symposia Medica Höchst 22: 419 (1988)
  8. Gleichmann, E., Vohr, H.-W., Stringer, C., Nuyens, J. and Gleichmann, H.
    Testing the sensitization of T cells to chemicals. From murine graft-versus-host (GvH) reactions to chemical-induced GvH-like immunological diseases.
    In: Autoimmunity and Toxicology; Kammüller, M.E., Bloksma, N. and Seinen, W. (Eds.); Elsevier, Amsterdam, 363 (1989)
  9. Reuter, R., Tessars, G., Vohr, H.-W., Gleichmann, E. and Lührmann, R.
    Mercuric chloride induces autoantibodies against U3 small ribonucleoprotein in susceptible mice.
    PNAS 86: 237 (1989)
  10. Pietsch, P., Vohr, H.-W., Degitz, K. and Gleichmann, E.
    Immunological alterations inducible by mercury compounds. II. HgCl2 and gold sodium thiomalate enhance serum IgE and IgG concentrations in susceptible mouse strains.
    Int. Arch. Allergy Appl. Immunol. 90: 47 (1989)
  11. Ochel, M., Vohr, H.-W., Pfeiffer, G. and Gleichmann, E.
    Immunpathological alterations by mercury compounds. IV. IL-4 dependency of increased IgE and IgG1 formation and of IgG1 autoantibodies.
    J. Immunology 146, 3006 (1991)
  12. Basketter, D. A., Bremmer, J. N., Kammüller, M. E., Kawabata, T., Kimber, I., Magda, S., Pal, T. H. M., Loveless, S. E., Stringer, D. A. and Vohr, H.-W.
    The identification of chemicals with sensitising or immunosuppressive properties in routine toxicology.
    Food and Chem. Tox. 32, 289-296 (1994)
  13. Vohr, H.-W., Homey, B., Schuppe, H. and Kind, P.
    Photoreactions detected in a modified local lymph node assay in the mouse.
    Photoderm., Photoimmunol. & Photomed. 10, 57-64 (1994)
  14. Homey, B., Vohr, H.-W. and Kind, P.
    UV-Dependent local lymph node assay: photoallergy and phototoxicity testing.
    In: Exogenous Dermatology - Advances in Skin-Related Allergology, Bioengineering, Pharmacology, and Toxicology, C. Surber, P. Elsner, A.J. Bircher (Eds.), Current Problems in Dermatology Vol. 22, 44-50, Karger-Verlag, Basel (1995)
  15. Basketter, D. A., Bremmer, J. N., Buckley, M. E., Kammüller, M. E., Kawabata, T., Kimber, I., Loveless, S., Magda, S., Stringer, D. A. and Vohr, H.-W.
    Pathology creteria for subsequent risk assessment of chemicals identified as immunosupressive in routine toxicology.
    Food and Chem. Tox., 33, 239-243 (1995)
  16. Vohr, H.-W.
    Experiences with an advanced screening procedure for the identification of chemicals with an immunotoxic potential in routine toxicology - a position paper.
    Toxicology, 104, 149-158 (1995)
  17. Vohr, H.-W.
    Toxikologische Prüfung von Pflanzenschutzmitteln mit besonderer Betonung immunologischer Untersuchungen.
    Bioscope, (1995)
  18. Richter-Reichhelm, H.-B., Dasenbrock, C., Descotes, G., Emmendörfer, A., Heinrich, U. E., Harlemann, J. H., Hildebrand, B, Küttler, K., Rühl-Fehlert, C. I., Schilling, K., Schulte, A. E. and Vohr, H.-W.
    Validation of a modified 28-Day rat study to evidence effects of test compounds on the immune system.
    Regulatory Toxikol. Pharmakol., 22, 54-56 (1995)
  19. Vohr, H.-W.
    Evaluation of toxicity to the immune system.
    In: Toxicology of Industrial Compounds. H. Thomas, R. Hess, F. Waechter (Eds.), Taylor & Francis-Verlag, London, 201-210 (1995)
  20. Lauerma, A. I., Homey, B., Vohr, H.-W., Lee, C. H., Bloom, E. and Maibach, H. I.
    Effect of topical cis-urocanic acid on local lymph node activation during contact sensitization: variability between mouse, rat and guinea pig.
    British J. Dermatol., 134, 904-909(1996)
  21. Ulrich, P. and Vohr, H.-W.
    Murine lymph node dendritic cells are the main source of interleukin-6 during initiation of delayed type hypersensitivity.
    European Cytokine Network, 7 (3),401-407(1996)
  22. Bomhard, E., Bomann, W., Heimann, K., Kroetlinger, F., Leser, K. H., Maertins, T., Pauluhn, J., Ramm, W., Schmidt, M. and Vohr , H.-W.
    Acute Toxicologic Evaluation of Eight Chemicals used in the Pharmaceutical Division.
    J. Am. Coll. Toxicol. 15, 94-103 (1996)
  23. Bomhard, E., Heimann, K., Löser, E., Märtins, T., Pauluhn, J., Ramm, W., Rossberg, W.M., Suberg, H., Stropp, G. and Vohr, H.W.
    Acute Toxicologic Evaluation of Desoxynojirimycin
    Int. J. Toxicol. 16 (2), 55, 1997
  24. Benton, W.P.M., Ulrich, P., Kuhn-Velten, W.N., Vohr, H.-W. and Wunderlich F.
    Testosterone-Induced Susceptibility to Plasmodium chabaudi Malaria: Persistence after Withdrawl of Testosterone.
    J. of Endocrinology 153 (2), 275-281, 1997
  25. Homey, B., Schuppe, H.-C., Assmann, T., Vohr, H.-W., Lauerma, A.I., Ruzicka, T. and Lehmann, P.
    A local lymph node assay to analyse immunosuppressive effects of topically applied drugs.
    Eur. J. Pharmacol. 325 (2-3), 199-207, 1997
  26. Homey, B., Neubert, T., Arens, A., Schuppe, H.-C., Ruzicka, T., Lehmann, P. and Vohr, H.-W.
    Sunscreen and Immunosuppression
    J. Invest. Dermatol., Letter to the editor 109(3), 395-396, 1997
  27. Homey B, Assmann T, Vohr H-W, Lauerma AI, Ruzicka T, Lehmann P, and Schuppe H-C:
    Topical FK506 suppresses cytokine and cell surface marker expression in epidermal and local draining lymph node cells during primary contact hypersensitivity responses.
    J Immunology 160 (11), 5331-5340, 1998.
  28. Ulrich, P., Homey, B. and Vohr, H.-W.
    A Modified Murine Local Lymph Node Assay for the Differentiation of Contact Photoallergy from Phototoxicity by Analysis of Cytokine Expression in Skin-Draining Lymph Node Cells.
    Toxicology 125, 149-168, 1998
  29. Bläß, St., Meier, C., Vohr, H.-W., Schwochau, M., Specker, C. and Burmester, G., R.
    The p68 autoantigen characteristic of rheumatoid arthritis is reactive with carbohydrate epitope specific autoantibodies.
    Ann. Rheum. Diseases 57(4), 220-225, 1998
  30. Homey, B, von Schilling, C., Blümel, J., Schuppe, H.-C., Ruzicka, T., Ahr, H.-J., Lehmann, P. and Vohr, H.-W.
    An Integrated Model for the Differentiation of Chemical-induced Allergic and Irritant Skin Reactions
    Toxicol. Appl. Pharmacol. 153, 83-94, 1998
  31. Schuppe, H.-C., Homey, B, Ulrich, P. and Vohr, H.-W.
    A Local Lymph Node Assay in Rats for Predicting Chemical-induced Contact and Photocontact Reactivity
    Dermatosen (Occupation and Environment) 47(1), 16-23, 1999
  32. Shinkai, K. et al.
    Mouse Popliteal Lymph Node Assay for Assessment of Allergic and Autoimmunity-Induced Potentials of Low-Molecular-Weight Drugs
    J. Toxicol. Sciences 24(2), 95-102, 1999
  33. Neumann, N.J., Homey, B., Vohr, H.-W. and Lehmann, P.
    Photoreactions.
    In: Cosmetics. Controlled Eficacy Studies and Regulations. Elsner, P., Merk, H.F. and Maibach, H.I. (Eds.). Springer Verlag, Berlin, 1999
  34. Vohr, H.-W., Wasinska-Kempka, G. and Ahr, H.J.
    An investigation into the phototoxic potential of moxifloxacin.
    In: Moxifloxacin in practice. 1999
  35. Blümel, J., Schimpl, A., Ulrich, P., Ahr, H.J. and Vohr, H.-W.
    Primary immune response in skin and skin-associated lymphoid tissue of interleukin-4 transgenic mice.
    Eur. Cytokine Netw. 10, 515-524, 1999
  36. Vohr, H.-W., Blümel, J., Blotz, A., Homey, B. and Ahr, H.J.
    An intra-laboratory validation of IMDS: Discrimination Between (Photo)Allergic and (Photo)Irritant Skin Reactions in Mice.
    Arch. Toxicol., 73, 501-509, 2000
  37. Neumann, N.J., Homey, B., Vohr, H.-W. and Lehmann, P.
    Methods for Testing the Phototoxicity and Photosensitization of Drugs.
    In: Biochemical Modulation of Skin Reactions, A. f. Kydonieus and J. J. Wille (Eds.), CRC Press, London, 2000
  38. Spielmann, H., Muller, L., Averbeck, D., Balls, M., Brendler-Schwaab, S., Castell, J. V., Curren, R., de Silva, O., Gibbs, N., K., Liebsch, M., Lovell, W., W., Merk, H. F., Nash, J., F., Neumann, N. J., Pape, W., J., Ulrich, P. and Vohr, H.-W.
    The second ECVAM Workshop on Phototoxicity Testing. The Report and Recommendations of ECVAM Workshop 42.
    Alternatives Lab. Anim. 28(6), 777-814, 2000
  39. Blotz, A., Michel, J., Moysan, A., Blümel, J., Dubertret, L., Ahr, H.J., and Vohr H.-W.
    Analyses of cutaneous fluoroquinolones photoreactivity using the integrated model for the differentiation of skin reactions.
    J. Photochem. Photobiol. 58, 46-53, 2000
  40. Vohr, H.-W. and Rühl-Fehlert, C.
    Industry experience in the identification of the immunotoxic potential of agrochemicals.
    Science Total Environm. 270, 123-134, 2001
  41. Richter-Reichhelm, H.-B. et al.
    Approaches to risk assessment of immunotoxic effects of chemicals (Meeting report).
    Toxicology 161, 213-228, 2001
  42. Suda, A., Yamashita, M., Tabei, M., Taguchi, K., Vohr, H.-W., Tsutsui, N., Suzuki, R., Kikuchi, K., Sakaguchi, K., Mochizuki, K. and Nakamura. K.
    Local lymph node assay with non-radioactive enpoints.
    J. Toxicol. Sci. 27(No.3) p205-218, 2001
  43. Ulrich, P., Grenet, O., Bluemel, J., Vohr, H.-W., Wiemann, C., Grundler, O. and Suter, W.
    Cytokine expression profiles during murine contact allergy: Th2 cytokines are expressed irrespective of the type of contact allergen.
    Arch. Toxicol. 75, 470-479, 2001
  44. Homey, B., P. Lehmann, and H. W. Vohr.
    Predictive immunotoxicological risk assessment.
    In: Toxicology of the Skin, H. I. Maibach (Edt), Taylor & Francis 357-371. 2001
  45. Pauluhn, J., Eidmann, P., Freyberger, A, Wasinska-Kempka, G., Vohr, H.-W.
    Respiratory Hypersensitivity to Trimellitic Anhydride in Brown Norway Rats: A comparison of endpoints.
    J. Applied Toxicol. 22, 89-97, 2002
  46. Vohr, H.-W., Pauluhn, J., Ahr, H. J.
    Respiratory hypersensitivity to trimellitic anhydride in Brown Norway rats: evidence for different activation pattern of immune cells following topical and respiratory induction
    Arch. Toxicol., 76, 538-544, 2002
  47. Kimber, I., Basketter, DA., Butler, M., Gamer, A., Garrigu, J-L, Gerberick, GF., Newsome, C., Steiling, W., Vohr, H.-W.
    Classification of contact allergens according to potency: proposals.
    Food Chem. Tox. 41, 1799-1809, 2003
  48. Ehling G, Hecht M, Heusener A, Huesler J, Gamer AO, v. Loveren, H., Maurer Th, Riecke K, Ullmann L, Ulrich P, Vandebriel R, Vohr H-W
    An European Inter-Laboratory Validation of Alternative Endpoints of the Murine Loacl Lymph Node Assay. First ROUND.
    Toxicology, 212, 60-68, 2005
  49. Ehling G, Hecht M, Heusener A, Huesler J, Gamer AO, v. Loveren, H., Maurer Th, Riecke K, Ullmann L, Ulrich P, Vandebriel R, Vohr H-W
    An European Inter-Laboratory Validation of Alternative Endpoints of the Murine Loacl Lymph Node Assay. 2nd ROUND.
    Toxicology, 212, 69-79, 2005
  50. Botham P, Urtizberea M, Wiemann C, Manciaux X, Tilbury L, Vohr HW, Allen S, Carmichael NG, de Jouffrey S.
    A comparative study of the sensitivity of the 3-induction and 9-induction Buehler test procedures for assessing skin sensitisation potential.
    Food Chem Toxicol. 43(1), 65-75, 2005
  51. Hoffmann J, Heisler E, Karpinski S, Losse J, Thomas D, Siefken W, Ahr HJ, Vohr HW and Fuchs HW
    Epidermal-Skin-Test 1000 (EST-1000) - A New Reconstructed Epidermis for in vitro Skin Corrosivity Testing.
    In vitro Toxicology 19, 925-9, 2005
  52. Ulrich P and Vohr HW
    Local Lymph Node Assay (IMDS), Modifications.
    In: Encyclopedic References of Immunotoxicology, H-W Vohr (Ed.), Springer, 2005
  53. Vohr HW
    Hypersensitivity Reactions.
    In: Encyclopedic References of Immunotoxicology, H-W Vohr (Ed.), Springer, 2005
  54. Van Loveren Henk and Vohr HW
    Host Resistance Assays.
    In: Encyclopedic References of Immunotoxicology, H-W Vohr (Ed.), Springer, 2005
  55. Vohr HW
    Guinea Pig Assays for Sensitization Testing.
    In: Encyclopedic References of Immunotoxicology, H-W Vohr (Ed.), Springer, 2005
  56. Vohr HW
    Delayed-Type Hypersensitivity.
    In: Encyclopedic References of Immunotoxicology, H-W Vohr (Ed.), Springer, 2005
  57. Vohr HW and Heisler E
    Three-Dimensional Human Skin/Epidermal Models and Organtypic Human and Mouse Skin Explant System.
    In: Encyclopedic References of Immunotoxicology, H-W Vohr (Ed.), Springer, 2005
  58. Neumann NJ, Blotz A, Wasinska-Kempka G, Lehmann P, Ahr HJ, Vohr HW
    Evaluation of phototoxic and photoallergic potentials of 13 compounds by different in vitro and in vivo methods.
    Photochem Photobiol 79, 25-34, 2005
  59. Vohr HW and Ahr HJ.
    Sensitivity of the LLNA
    Archive of Toxicol. 79, 721-8, 2005
  60. Pauluhn J and Vohr HW.
    Partial C-Fiber Ablation Modulates Diphenylmethane-4,4´-Diisocyanate (MDI)-Induced Respiratory Allergy in Brown Norway Rats.
    Toxicology 228, 188-199, 2006
  61. Carfi' M, Gennari A, Malerba I, Corsini E, Pallardy M, Pieters R, Van Loveren H, Vohr HW, Hartung T, Gribaldo L.
    In vitro tests to evaluate immunotoxicity: A preliminary study.
    Toxicology , 2006
  62. Weiland C, Ahr HJ, Vohr HW, Ellinger-Ziegelbauer H.
    Characterization of primary rat proximal tubular cells by gene expression analysis.
    Toxicol In Vitro, 466-491, 2007
  63. Ulrich P, Vohr HW.
    Utilization of irritation Data in the Local Lymph Node Assay
    In: Zai and Maibach: Dermatotoxicology, 7th Edition, 2007
  64. Steiling W, Vohr HW.
    Regulatory assessment of skin sensitization
    In: Roberts and Walters: Dermal Absorption and Toxicity Assessment, 2nd Edition, 2007
  65. Koeper LM, Schulz A, Ahr HJ, Vohr HW.
    In vitro differentiation of skin sensitizers by cell signaling pathways.
    Toxicology. 242, 2007, 144–152
  66. Vohr, HW.
    New approaches to hazard identification: Non-radioactive alternatives
    In: van Loveren, H. Et al.: Skin sensitization in chemical risk assessment: Report of a WHO/IPCS international workshop focusing on dose–response assessment. Reg. Tox. Pharmacol., 50, 2008, 155-199
  67. Gamer AO, Nies E and Vohr HW
    Local lymph node assay (LLNA): comparison of different protocols by testing skin-sensitizing epoxy resin system components
    Reg. Tox. Pharmacol.52, 2008, 290–298
  68. Koeper LM and Vohr HW.
    Functional Assays are Mandatory for a Correct Prediction of Immunosppressant Properties of Compounds in vitro
    Food and Chem Tox, 47, 2009, 110-8. (Epub 2008)
  69. Hothorn, L.A., Vohr, H-W.
    Statistical Evaluation of the Local Lymph Node Assay
    Reg. Tox. Pharmacol. 56, 2010, 352-6 (Epub 2009)
  70. Delić D, Gailus N, Vohr HW, Dkhil M, Al-Quraishy S and Wunderlich F.
    Testosterone-induced permanent changes of hepatic gene expression in female mice sustained during Plasmodium chabaudi malaria infection.
    J. Mol. Endocrinol. 45, 2010, 379-90
  71. Delić D, Ellinger-Ziegelbauer H, Vohr HW, Dkhil M, Al-Quraishy S, Wunderlich F.
    Testosterone response of hepatic gene expression in female mice having acquired testosterone-unresponsive immunity to Plasmodium chabaudi malaria.
    Steroids. 2011 Jun 12. [Epub ahead of print]
  72. Fischer A, Koeper LM, Vohr HW.
    Specific antibody responses of primary cells from different cell sources are able to predict immunotoxicity in vitro.
    Toxicol In Vitro. Jul 6. [Epub ahead of print], 2011
  73. Bhalli, JA, Shaddock, JG, Pearce, MG, Dobrovolsky, VN, Cao, X, Heflich, RH, Vohr, HW.
    Report on Stage III Pig-a Mutation Assays Using Benzo[a]pyrene.
    Environmental and MolecularMutagenesis, 2011

Others:

  1. Vohr, H.-W. und Schimpl, A.
    Monoklonale Ak gegen humanes IL-2. Optimierung des ELISA zum Nachweis von humanem IL-2 mit mAk.
    In: Jahresbericht des BMFT (1986)
  2. Gleichmann, E., Vohr, H.-W., Mirtschewa, J., Stiller-Winkler, R. und Vogeler, S.
    Zur Induktion von Autoimmunkrankheiten und anderen stimulativen Immunopathien durch Quecksilber und andere Chemikalien.
    Umwelthygiene 19: 270 (1986/1987)
  3. Vohr, H.-W,, Kubicka-Muranyi, M. und Gleichmann, E.
    Entwicklung des Poplitealenlymphknotentests: Ein einfacher Funktionstest zur Erkennung sensibilisierender Chemikalien und ihrer Metaboliten.
    Umwelthygiene 21: 203 (1988/1989)
  4. Basketter, D.A., Bremmer, J. N., Kammüller, M. E., Kawabata, T., Kimber, I., Loveless, S. E., Stringer, D. A. and Vohr, H.-W.
    Immunotoxicity: hazard identification and risk characterisation.
    Monograph No. 21, ECETOC, Brussels (1994)
  5. Vohr, H.-W.
    Immunotoxicology and Immunopharmacology.
    Dean, J. H., Luster, M. I., Munson, A. E. and Kimber, I. (Eds.), Raven Press (1994). Book review in EFBS-Letters, (1995)
  6. Richter-Reichhelm, H.-B., Althoff, J., Dasenbrock, C., Descotes, G., Emmendörfer, A., Ernst, H., Harlemann, J. H., Hildebrand, B, Küttler, K., Rühl-Fehlert, C. I., Schilling, K., Schulte, A. E. and Vohr, H.-W.
    Evaluation of the Appropriateness of the Extended Subacute (28 Day-) Toxicity Test to Detect Adverse Effects on the Immune System.
    BGVV Hefte, 4 (1996)
  7. Basketter, D.A., Butler, M. Gamer, A., Garruige, J.-L., Gerberick, G.F., Kimber, I., Newsome, C., Steiling, W. and Vohr, H.-W.
    Contact Sensitisation: Classification According to Potency
    Technical Report No. 78, ECETOC, Brussels (2003)

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